Granular Cell Tumour of the Tongue: A Case Report of the Rare Lesion

Main Article Content

Babalola Oluwole Castano
Samuel Olalekan Keshinro
Remilekun Oluwatosin Oluwakuyide
Clement Akanbi Oluwarotimi

Keywords

immunohistochemistry, tongue, tumour, Granular cell

Abstract

Granular Cell Tumour (GCT) is a rare and painless benign soft tissue neoplasm of Schwann cell derivative. It is a slow-growing, firm, and solitary nodule usually smaller than 3 cm in diameter that frequently occurs in females between 4th-6th decade of life. We aim to describe the clinical presentation of the granular cell tumour (GCT) and the histopathological tools used to achieve its definitive diagnosis.We present a case of GCT of the tongue in a 46-year old female who presented with a year-old painless swelling on the tongue in our dental clinic. There was associated tenderness but disturbed deglutition. Clinical examination revealed a firm swelling in the right anterior two-thirds. Differential diagnoses made were chondroma, fibroma, and rhabdomyoma. Excisional biopsy for histopathological and immunohistochemical evaluation was diagnostic of GCT.GCT may be confused with other oral lesions clinically, but the use of histopathological and immunohistochemical tools confirmed its diagnosis.

Abstract 28 | PDF Downloads 10 EPUB Downloads 17

References

1. Aoyama K, Kamio T, Hirano A, Seshimo A, Kameoka S. Granular Cell Tumours: A report of six cases. World Journal of Surgical Oncology. 2012, 10:204.
2. Neelon D, Lannan F, Childs J. Granular Cell Tumour. 2023 Jul 3. In:StatPearls. Treasure Island(FL): StatPearls Publishing; 2025 Jan. https://www.ncbi.nlm.gov/books/NBK563150
3. Van de loo S, Thunnissen E, Postmus P, van der waal I. Granular Cell Tumour of the oral cavity; a case series including a case of metachronous occurrence in the tongue and the lung. Med Oral Patol Oral Cir Buccal. 2014 Jun; 20(1):e30-e33.
4. Stemm M, Suster D, Wakely PE, Suster S. Typical and Atypical Granular Cell Tumors of tissue: A clinicopathologic Study of 50 Patients. Am J Clin Pathol. 2017 Aug; 148(2): 161-166.
5. Fahim S, Aryanian Z, Ebrahimi Z, Kamyab-Hesari K et al. Cutaneous granular cell tumor: A case series, review and update. J Family Med Prim Case. 2022 Dec; 11(11): 6955-6958.
6. Sposto RM, Navarro CM, de Andrade CR. Granular cell tumour (Abrikossff’s tumour): Case series. Oral Oncology Extra, 2006 May; 42(5):194-197.
7. Castano BO, Oluwarotimi AC, Adesina OA, Ayodele AOS. Congenital Granular Cell of the New Born: A case report of the rare lesion. Ann Ibd. Pg. Med. 2020 Dec; 18(2): 163-166.